Home  >  Products  >  AMP Activated Protein Kinase gamma1 (AMPK gamma-1 Chain, AMPK Subunit gamma-1, AMPK gamma1, AMPK g1, AMPKg, 5'-AMP-activated Protein Kinase Subunit gamma-1, MGC8666, PRKAG1)
AMP Activated Protein Kinase gamma1 (AMPK gamma-1 Chain, AMPK Subunit gamma-1, AMPK gamma1, AMPK g1, AMPKg, 5'-AMP-activated Protein Kinase Subunit gamma-1, MGC8666, PRKAG1)

AMP Activated Protein Kinase gamma1 (AMPK gamma-1 Chain, AMPK Subunit gamma-1, AMPK gamma1, AMPK g1, AMPKg, 5'-AMP-activated Protein Kinase Subunit gamma-1, MGC8666, PRKAG1)

Cat no: A1475-08G

Supplier: United States Biological
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AMPK gamma-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta- methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: ELISA: 0.25ug/ml Western Blot: 0.5-2.5ug/ml Immunohistochemistry: 2.5-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A1475-08G
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G afinity chromatography.
Alternative names: Protein Kinase AMP-activated gamma 1 Non-catalytic Subunit
References: 1.Minokoshi, Y., et al., Nature 428(6982):569-574 (2004). 2.Andersson, U., et al., J. Biol. Chem. 279(13):12005-12008 (2004). 3.Landree, L.E., et al., J. Biol. Chem. 279(5):3817-3827 (2004). 4.Carling, D., Trends Biochem. Sci. 29(1):18-24 (2004). 5.Shaw, R.J., et al., Proc. Natl. Acad. Sci. U.S.A. 101(10):3329-3335 (2004).
Additional info: Recognizes human AMPK gamma. Species crossreactivity: mouse.

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