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AMPD1 (AMP Deaminase 1, AMP Deaminase Isoform M, Myoadenylate Deaminase)

AMPD1 (AMP Deaminase 1, AMP Deaminase Isoform M, Myoadenylate Deaminase)

Cat no: A5801-01C

Supplier: United States Biological
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AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP liberating ammonia. There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. This protein is the predominant member of AMPD multi-gene family and is considered as the sensor of the cell's changing energy requirements. AMPD1 deficiency causes irregular muscle metabolism due to lower rate of ATP degradation, phosphocreatine hydrolysis and accumulation of lactic acid. Mutated AMPD1 expression has been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies and congestive heart failures due to coronary artery diseases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Testis Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A5801-01C
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Sanz et.al. Physiol Genomics. 14:161-166 (2003). 2. Lucia et.al. Br J Sports Med 40 (3) e7-e7 (2006).
Additional info: Recognizes human AMPD1. Species Crossreactivity: bovine, canine, monkey, mouse, ratSpecies sequence homology: chimpanzee, zebrafish.

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