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Amphiphysin (AMPH, AMPH1)

Amphiphysin (AMPH, AMPH1)

Cat no: A1580-03D

Supplier: United States Biological
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Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrinmediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:2,000 Immunoprecipitation: 1-2ul/400ul lysates Immunohistochemistry: 1:100 Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Catalogue number: A1580-03D
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid in Hepes, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG1,k
Purity: Ascites
References: 1. Zhang, B. and Zelhof, A.C. (2002) Traffic, 3:452-460, 2. Wigge, P. and McMahon, H.T. (1998) Trend:Neurosci. 21, 339-344.
Additional info: Recognizes human Amphiphysin. Species crossreactivity: mouse, rat.

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