Home  >  Products  >  AMPK, gamma3 (AMP Activated Protein Kinase gamma3, PRKAG3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, AMPKG3, 5'-AMP-activated protein kinase, gamma-3 Subunit, AMP-activated protein kinase, non-catalytic gamma-3 Subunit)
AMPK, gamma3 (AMP Activated Protein Kinase gamma3, PRKAG3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, AMPKG3, 5'-AMP-activated protein kinase, gamma-3 Subunit, AMP-activated protein kinase, non-catalytic gamma-3 Subunit)

AMPK, gamma3 (AMP Activated Protein Kinase gamma3, PRKAG3, protein kinase, AMP-activated, gamma 3 non-catalytic subunit, AMPKG3, 5'-AMP-activated protein kinase, gamma-3 Subunit, AMP-activated protein kinase, non-catalytic gamma-3 Subunit)

Cat no: A1475-08F

Supplier: United States Biological
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The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A1475-08F
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by affinity chromatography.
References: 1. Costford SR, Kavaslar N, Ahituv N, Chaudhry SN, Schackwitz WS, Dent R, Pennacchio LA, McPherson R, Harper ME. Gain-of-function R225W mutation in human AMPKgamma3 causing increased glycogen and decreased triglyceride in skeletal muscle. PLoS ONE. 2007 Sep 19;2(9):e903. PMID: 17878938
Additional info: Recognizes human AMPK, gamma3. Species sequence homology: bovine.

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