AMSH, Recombinant, Human (STAM Binding Protein, STAMBP)

Associated Molecule with the SH3 Domain of STAM (AMSH), also known as STAM Binding Protein (STAMBP), is a 424 amino acid (aa) zinc metalloprotease member of the peptidase M67C class of enzymes with a predicted molecular weight of 50kD. The mouse and rat AMSH/STAMBP orthologs share 83% and 84% aa sequence identity with the human protein, respectively. AMSH/STAMBP is ubiquitously expressed and functions at endosomes where it opposes Ubiquitin-dependent sorting and recycling of receptors to lysosomes. The ability of AMSH/STAMBP to cleave K63-linked, but not K48-linked, poly-Ubiquitin chains is mediated by a JAMM motif (aa 335-348).1 Receptor substrates for AMSH/STAMBP include EGF R and Erb2. AMSH/STAMBP also functions in cytokine signaling and participates in cMyc induction by IL-2 or GM-CSF, as well as bone morphogenic protein (BMP) signaling via inhibition of Smad proteins. AMSH/STAMBP knockout mice show early-onset neurodegeneration and increased protein deposits in the brain, suggesting that AMSH/STAMBP may contribute to neurodegenerative diseases such as Alzheimer

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SPECIFICATIONS

Catalog Number

145775

Size

25ug

Form

Supplied as a liquid in 50mM HEPES, pH 8.0, 150mM sodium chloride, 1mM TCEP, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Agromayor, M. and Martin-Serrano, J. (2006) J. Biol. Chem 281:23083-23091. 2. Kim, M.S., et al (2006) Biochem. Biophys. Res Comm. 351:612-618 3. McCullough, J., et al (2006) Current Biology 16:160-165. 4. Sato, Y., et al (2008) Nature. 455:358-362.