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Amyloid A4 (Amyloid beta) Variant 40

Amyloid A4 (Amyloid beta) Variant 40

Cat no: A2275-59F

Supplier: United States Biological
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Alzheimers disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Ab4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). The amyloid beta-protein precursor (APP) is proteolytically cleaved to generate the 4kDa Ab4 protein. Two variants of Ab4 can be detected; Ab-40 short-tailed and Ab-42 long-tailed (3-4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500 (5ng) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: A2275-59F
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Glenner, G. G, et al. (1984) Biochem. Biophys. Res. Commun. 120, 885-890 2. Masters, C. L., et al. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249 3. Dovey, H., et al. (1993) NeuroReport 4, 1039-1042 4. Vigo-Pelfrey, C., et al (1993) J. Neurochem. 61, 1965-1968
Additional info: Recognizes human Amyloid A4.

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