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Amyloid Beta, 1-40 (Amyloid A4)

Amyloid Beta, 1-40 (Amyloid A4)

Cat no: A2275-59D1

Supplier: United States Biological
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In the brains of patients with Alzheimer's disease, amyloid composed of 4kD amyloid beta protein is deposited in senile plaques and in blood vessel walls. Amyloid beta protein is a 39-43aa polypeptide with heterogeneous termini that is generated from the cleavage of a larger amyloid precursor protein (APP), which under appropriate cellular conditions, aggregate as senile plaques, which is a critical step in the neurodegenerative processes associated with AD. Cleavgae of the transmembrane region of APP by
Catalogue number: A2275-59D1
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Ascites
References: 1. Kang et al. Nature 325: 733, 1987. 2. Tanzi et al. Nature 331: 528, 1988. 3. Weidemann et al. Cell 57: 115, 1989. 4. Yanker et al. Science 245: 417, 1989. 5. Gralle et al. Prog Neurobiol 82: 11, 2007. 6. Gravina et al. Journal of Biological Chemistry 270: 7013, 1995.
Additional info: Recognizes human Amyloid beta Protein.

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