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Amyloid Beta, 1-40 (Amyloid A4)

Cat no: A2275-59D1

Amyloid Beta, 1-40 (Amyloid A4)

In the brains of patients with Alzheimer's disease, amyloid composed of 4kD amyloid beta protein is deposited in senile plaques and in blood vessel walls. Amyloid beta protein is a 39-43aa polypeptide with heterogeneous termini that is generated from the cleavage of a larger amyloid precursor protein (APP), which under appropriate cellular conditions, aggregate as senile plaques, which is a critical step in the neurodegenerative processes associated with AD. Cleavgae of the transmembrane region of APP by

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SPECIFICATIONS

Catalog Number

A2275-59D1

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

1. Kang et al. Nature 325: 733, 1987. 2. Tanzi et al. Nature 331: 528, 1988. 3. Weidemann et al. Cell 57: 115, 1989. 4. Yanker et al. Science 245: 417, 1989. 5. Gralle et al. Prog Neurobiol 82: 11, 2007. 6. Gravina et al. Journal of Biological Chemistry 270: 7013, 1995.

Additional Info

Recognizes human Amyloid beta Protein.

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