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Amyloid Beta, 1-40 (Amyloid A4)

Amyloid Beta, 1-40 (Amyloid A4)

Cat no: A2275-59V

Supplier: United States Biological
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Alzheimer's Disease (AD) is the most common neurodenerative disorder in elderly people. It has been demonstrated that AD has biological cause and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. beta-Amyloid 1-40 (Ab40) and beta-amyloid 1-42 (Ab42) are the main components of the above plaques; however, other forms of amyloid-beta peptides also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by b-secretase and g-secretase enzymes. Many studies suggest that Ab42 or/and Ab43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration while Ab40 is less neurotoxic. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Immunohistochemistry: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2275-59V
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Levites, Y. et al. J. Clin. Invest. 116(1): 193-201: 2006. 2. Broersen, K. et al. Alzheimer's Res. Ther. 2: 1-14, 2010. 3. Zhang, Y-W. et al. Mol. Brain 4: 1-13: 2011. 4. Koechling, T. et al. Int. J. Alzheimer's Dis. 2010. 5. Bobba, A., et al. Int. J. Alzheimer's Dis. 2010.
Additional info: Recognizes beta-amyloid. Species Crossreactivity: human, mouse and rat.

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