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Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65, MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein)

Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65, MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein)

Cat no: A2275-61P2

Supplier: United States Biological
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FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients. Positive Control: IMR32 neuronal cell lysate, HEK 293 cell lysate, or brain lysate Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2275-61P2
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: PBS, 15% glycerol
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zambrano, N., et al. Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of FE65 with Wild-type and Mutant Alzheimer's beta-amyloid Precursor Proteins. JBC. 272:6399-405 (1997). [Western Blot, Immunoprecipitation] 2. Cao, X., and Sudhof, TC. A Transcriptionally active complex of APP with FE65 and Histone Acetylase TIP60. Science. 293:115-120 (2001). 3. Guenette, S., et al. Essential Roles for the FE65 Amyloid Precursor Protein-interaction Proteins in Brain Development. EMBO. 25:420-431 (2006). [Immunohisto/cytochemistry] 4. Muller, T., et al. Modulation of Gene Expression and Cytoskeletal Dynamics by the APP Intracellular Domain. MBC. Ahead of publication.
Additional info: Species Crossreactivity: This antibody reacts with the human and mouse proteins.

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