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Amyloid Beta, aa1-8 (NT) (Amyloid A4)

Cat no: A2275-59P

Amyloid Beta, aa1-8 (NT) (Amyloid A4)

Beta amyloid is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In come cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased product of amyloid. Researchers have been looking at how presenilins-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Presenilin-1 might be gamma-secretase.\n\nApplications: \nSuitable for use in Dot Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nDot Blot: 1:100-1:1,000\nImmunohistochemistry: 1:100-1:1,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A2275-59P

Size

200ul

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS.

P Type

Mab

Purity

Purified by ammonium sulfate precipitation.

Isotype

IgG1

Additional Info

Recognizes the amino terminal region (aa1-8) of human beta amyloid peptide. Highly reactive to Amyloid beta form of APP.

Read more on Supplier website

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info
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