Amyloid beta Protein

Beta amyloid protein is 4.2-kD polypeptide. Glenner and Wong (1984) purified a protein derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease. The proteins from both disorders have an identical 28-amino acid sequence. memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly. Amyloid beta protein (Abeta) deposition in the brain is a hallmark of Alzheimer's disease (AD).\n\nApplications:\nSuitable for use in Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144155

Size

100ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG1

References

1. Lesne, S.; Koh, M. T.; Kotilinek, L.; Kayed, R.; Glabe, C. G.; Yang, A.; Gallagher, M.; Ashe, K. H. : A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440: 352-357, 2006.\n2. Lorenzo, A.; Yuan, M.; Zhang, Z.; Paganetti, P. A.; Sturchler-Pierrat, C.; Staufenbiel, M.; Mautino, J.; Vigo, F. S.; Sommer, B.; Yankner, B. A. : Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nature Neurosci. 3: 460-464, 2000.

Additional Info

Recognizes human Amyloid beta Protein. No crossreactivity with other proteins.