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Amyloid Oligomers (A11, Amyloid Oligomer AlphaBeta)

Cat no: 136753

Amyloid Oligomers (A11, Amyloid Oligomer AlphaBeta)

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils.\nAmyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-b peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer

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SPECIFICATIONS

Catalog Number

136753

Size

100ul

Applications

ELISA, ICC, IF, IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

References

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Additional Info

Recognizes all types of amyloid oligomers. Recognizes a peptide backbone epitope that is common to amyloid oligomers, but not found in native proteins, amyloidgenic monomer or mature amyloid fibrils. Species Crossreactivity: Eukaryotes, human, mouse and rat.

Alternative Names

A11, Amyloid Oligomer AlphaBeta

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