Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)

Serum amyloid P component or SAP or APCS, or PTX2 (mature chain 204 aa, chromosome 1q21-23) with which CRP has about 59% homology, is situated in the same area of chromosome 1. SAP is universally present in amyloid deposits 9senile plaque and neurofibrially tangels) in Alzheimers patients. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A-beta deposition since no endogenous SAP immunoreactivity was found in mice overexpressing APP.\nIn mice with a targeted deletion of the SAP gene, induction of reactive amyloidosis was retarded, demonstrating the participation of SAP in pathogenesis of amyloidosis in vivo and confirming that inhibition of SAP binding to amyloid fibrils is an attractive therapeutic target. SAP knock out mice develop antinuclear autoimmunity and glomerulonephritis. However the exact role of SAP in SLE is not clear. SAP also neutralizes LPS and it is potentially useful in defense against serious gram-negative sepsis.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 1:500-1:20,000\nWestern Blot: 1:500-1:5000\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide:\nA2275-88F: Amyloid P Component, Serum, Human (SAP, APCS, PTX2, mature chain 204aa, chromosome 1q21-23)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2275-88J

Size

50ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS.

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG1

References

1. Mortensen, R.F., Immunogenetics 22: 367-375 (1985). 2. Whitehead, A.S., et al., Immunogenetics 28: 388-390 (1988). 3. Mantzouranis, E.C., et al., J. Biol. Chem. 260: 7752-7756 (1985). 4. Botto, M., et al., Nature Med. 3: 855-859 (1997). 5. Pepys, M.B., et al., Nature 278, 259 (1979).

Additional Info

Recognizes human SAP. Does not crossreact with CRP or other pentraxins. Species Crossreactivity: minimal crossreactivity with mouse SAP.