Home  >  Products  >  Amyloid Precursor Protein (Amyloid beta (A4) Precursor Protein, APP, ABPP, Amyloid beta A4 Protein, Alzheimer Disease Amyloid A4 Protein Homolog, Amyloidogenic Glycoprotein, AG)
Amyloid Precursor Protein (Amyloid beta (A4) Precursor Protein, APP, ABPP, Amyloid beta A4 Protein, Alzheimer Disease Amyloid A4 Protein Homolog, Amyloidogenic Glycoprotein, AG)

Amyloid Precursor Protein (Amyloid beta (A4) Precursor Protein, APP, ABPP, Amyloid beta A4 Protein, Alzheimer Disease Amyloid A4 Protein Homolog, Amyloidogenic Glycoprotein, AG)

Cat no: A2275-86E

Supplier: United States Biological
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Accumulation of the amyloid-b peptide (Ab) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by b-secretase, resulting in a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kD amyloid-b peptide (Ab), that is deposited in the brain of patients of Alzheimer's disease. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Mouse or rat brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2275-86E
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ponte P, et al. Nature 331:525-7 (1988). 2. Selkoe DJ, et al. Annu Rev Cell Biol 10:373-403 (1994).
Additional info: Recognizes human APP. Species Crossreactivity: mouse and rat. Species sequence homology: chicken and monkey.

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