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Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Amyloid Precursor Protein (APP, Amyloid beta (A4) Precursor Protein)

Cat no: A2275-87R

Supplier: United States Biological
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The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5ug/ml Immunohistochemistry (Paraffin): 1:100 Optimal dilutions to be determined by the researcher. Positive Control: Human Alzheimer's diseased brain tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2275-87R
Reactivities: Human, Mouse
Hosts: Mouse
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human Amyloid beta A4 Protein at ~4kD. Species Crossreactivity: mouse.

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