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Amyloid Precursor Protein, Secretory (sAPP)

Amyloid Precursor Protein, Secretory (sAPP)

Cat no: A2275-71H1

Supplier: United States Biological
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Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr 100kD and a C-terminal fragment (C99) with Mr 12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer
Catalogue number: A2275-71H1
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by affinity chromatography.
References: 1) Miyazaki, K., Hasegawa, M., Funahashi, K., and Umeda. M. (1993) Nature 362, 839-841. 2) Kihara, Y. and Aiba, S. (1992) J. Chromatogr. 597, 277-283.
Additional info: Recognizes secretory amyloid protein precursor (sAPP). Does not recognize bAP1-40.

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