Home  >  Products  >  Androgen Receptor (AR, AIS, Dihydrotestosterone Receptor, DHTR, KD, HUMARA, HYSP1, Nuclear Receptor Subfamily 3 Group C Member 4, NR3C4, SBMA, SMAX1, TFM)
Androgen Receptor (AR, AIS, Dihydrotestosterone Receptor, DHTR, KD, HUMARA, HYSP1, Nuclear Receptor Subfamily 3 Group C Member 4, NR3C4, SBMA, SMAX1, TFM)

Androgen Receptor (AR, AIS, Dihydrotestosterone Receptor, DHTR, KD, HUMARA, HYSP1, Nuclear Receptor Subfamily 3 Group C Member 4, NR3C4, SBMA, SMAX1, TFM)

Cat no: A2281-04A

Supplier: United States Biological
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Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in the androgen target genes. AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3). Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence (IF-IC): 1:600 Flow Cytometry: 1:400 Western Blot: 1:2000 Incubate membrane with diluted antibody in 5% nonfat dry milk, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Immunohistochemistry (Paraffin): 1:400 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2281-04A
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Purified
References: (1) Li, J. and Al-Azzawi, F. (2009) Maturitas 63, 142-8. (2) Avila, D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76, 135-142. (3) Montgomery, J.S. et al. (2001) J. Pathol. 195, 138-146.
Additional info: Recognizes endogenous levels of total androgen receptor.

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