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Androgen Receptor (AR, DHTR, Dihydrotestosterone Receptor, NR3C4, Nuclear receptor subfamily 3 Group C Member 4)

Androgen Receptor (AR, DHTR, Dihydrotestosterone Receptor, NR3C4, Nuclear receptor subfamily 3 Group C Member 4)

Cat no: A2281-13C

Supplier: United States Biological
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The Androgen Receptor (AR) is a 90kD steroid hormone receptor that is critical for the development and function of the male reproductive system. AR binding to testosterone or 5a-dihydrotestosterone (DHT) triggers receptor dimerization followed by translocation to the nucleus where it promotes transcription of androgen responsive genes. Multiple polymorphisms in AR are linked to the development of prostate cancer. The ligand binding domain of human AR aa661-920 shares aa sequence identity with mouse and rat AR. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): 8-25ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2281-13C
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with 200ul sterile PBS.
P type: Mab
Isotype: IgG2A
Purity: Purified by Protein A/G affinity chromatography.
Additional info: Recognizes human Androgen R/NR3C4. Species Crossreactivity: mouse and rat

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