Androgen Receptor (AR, KD, AIS, TFM, DHTR, SBMA, NR3C4, SMAX1, HUMARA, androgen receptor (dihydrotestosterone receptor testicular feminization spinal and bulbar muscular atrophy Kennedy disease), dihydrotestosterone receptor)

The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed as a marker of hormone-responsiveness.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested. \n\nRecommended Dilutions: \nELISA:1:64000\nWestern Blot: 0.3-2ug/ml. ~95kD band observed in Human Brain and Human Heart lysates (calculated MW of 99kD). Optimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nPeptide Blocking:\nCorresponding peptide is available for Peptide Blocking studies. See A2281-01B-P. Antibody

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SPECIFICATIONS

Catalog Number

A2281-01B

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Rat, NHP

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

Trapman J, Klaassen P, Kuiper GG, van der Korput JA, Faber PW, van Rooij HC, Geurts van Kessel A, Voorhorst MM, Mulder E, Brinkmann AO. , Cloning, structure and expression of a cDNA encoding the human androgen receptor., Biochem Biophys Res Commun. 1988 May 31;153(1):241-8.

Additional Info

Recognizes Human Androgen Receptor. Species Sequence Homology: Mouse, Rat, and Chimpanzee.