Androgen receptor (AR) belongs to the super-family of nuclear hormone receptors that employ complex molecular mechanisms to guide the development and physiological functions of their target tissues. Extensive research over the past several years has explored the possible mechanisms of steroid receptor action. The group of co-regulators includes co-activators, co-repressors, cointegrators and mediator protein complexes. Each of these proteins potentially interacts with multiple signaling systems, including most steroid receptors. In mammals, exposure to androgens early in development is essential for masculinization of the male reproductive phenotype. Androgen stimulation results in cell proliferation in both the development of prostate and malignant prostate. Data from animal and human studies indicate that sex steroids have important skeletal effects. Androgens clearly enhance bone size, likely through effects on periosteal bone formation. Similarly to other steroid receptors, AR is a phosphoprotein, but the functional significance of the covalent receptor modification by phosphorylation has remained enigmatic.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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