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Angiopoietin-1, Recombinant, Human (Ang-1, Ang1, Angpt1)

Cat no: 044502


Supplier: United States Biological
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Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. Biological Activity: Induces phosphorylation of Tie-2 in primary cultured human vascular endothelial cells (HUVECs). The protein forms mainly tetrameric structures. Sequence: Human angiopoietin-1 (aa 20-498) is fused at the N-terminus to a FLAG(R)-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 044502
Size: 10ug
Form: 0.2um-filtered solution in PBS 0.02% CHAPS.
Purity: >90% (SDS-PAGE)
Alternative names: Ang-1, Ang1, Angpt1
Additional info: Binds to human Tie-2.

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