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Angiostatin

Cat no: A2294-07A

Angiostatin

Angiostatin is a proteolytic fragment that comprises the first four kringle domains of the ~85kD plasminogen. Angiostatin reduces endothelial cell proliferation and acts as an \npotent inhibitor of angiogenesis and tumor growth. \n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 2ug/ml. Detects a 50kD protein representing recombinant human angiostatin. \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2294-07A

Size

100ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Sim BK et al. Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev 19:181-90 (2000). 2. Drixler TA et al. Angiogenesis and surgery: from mice to man. Eur J Surg 166:435-46 (2000).

Additional Info

Recognizes recombinant mouse angiostatin. Species crossreactivity: human

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