Angiotensin Converting Enzyme 2 (ACE-2, ACEH) Ectodomain

Angiogensin I Converting Enzyme-2 (ACE-2) is a type I transmembrane zinc protease that \ncleaves angiotensins I and II to produce vasodilatory and anti-proliferative peptides. The \nbalance between ACE-1 and ACE-2 activity is critical for maintaining cardiovascular, renal, \nand pulmonary function. ACE-2 isoforms of 75kD and 120kD are differentially expressed \nbetween lung and kidney, respectively, and a shed soluble form is generated by \nTACE/ADAM17 mediated cleavage. ACE-2 also functions as the cellular uptake receptor for \nthe SARS coronoavirus. Within the extracellular domain, human ACE-2 shares 83% aa \nsequence identity with mouse and rat ACE-2. \n \nApplications: \nSuitable for use in ELISA, Western Blot, Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.5-1.0ug/ml\nWestern Blot: 2ug/ml\nImmunohistochemistry: 25ug/ml\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nMouse myeloma with B cells obtained from a mouse.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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