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Angiotensin II Antibody

Angiotensin II Antibody

Cat no: 251229

Supplier: ABBIOTEC
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Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal corte, Xenopus/Amphibian, to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
Catalogue number: 251229
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P01019
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human angiotensinogen II.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: Ang-II; Ang II; Angiotensin II; Angiotensin-2; AGT; Angiotensinogen; Serpin A8
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