ANGPTL3, Recombinant, Human (Angiopoietin-related Protein 3, Angiopoietin-5, ANG-5, Angiopoietin-like Protein 3, ANGPT5, UNQ153/PRO179)

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietinfamily of structurally related proteins, characterized by a coiled N-terminaldomain and a C-terminal fibrinogen like domain. It is primarily expressed inthe liver and can exert activities related to both angiogenesis and lipidmetabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase(EL), which has the effect of increasing plasma levels of triglycerides and HDLassociated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein canbind alpha-5/beta-3 integrins leading to endothelial cell adhesion and migration. Recombinant human ANGPTL-3 isa glycoprotein that migrates by SDS-PAGE analysis at an apparent molecularweight of 62kD, and contains 452aa residues including a C-terminal His tag.\n\nBiological Activity:\nMeasured by its binding ability to recombinant alpha v beta 3 integrin in a functional ELISA.\n\nAA Sequence:\nSRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRIDGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIELE DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLVFSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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