ANGPTL6 (human) BioAssay(TM) ELISA Kit (Angiopoietin-like Protein 6, AGF, Angiopoietin-related Growth Factor)

Seven proteins containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristics of angiopoietins, have been identified and therefore designated angiopoietin-like proteins 1-7 (ANGPTL 1-7). ANGPTL3 and ANGPTL6 (Angiopoietin-related growth factor; AGF), among others, function to regulate angiogenesis and also appear to directly regulate lipid, glucose, and energy metabolism. The serum levels of ANGPTL6 are significantly increased in obese humans, patients with type 2 diabetes mellitus (T2DM), and in metabolic syndrome. Therefore, ANGPTL6 may be a novel biomarker for metabolic diseases and may provide a novel therapeutic approach to counteract obesity, T2DM and insulin resistance.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

044549

Size

96Tests

References

Product Reference: \n?Serum levels of angiopoietin-related growth factor are increased in preeclampsia: H. Stepan, et al.; Am. J. Hypertens. 22, 314 (2009)\n?Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis: T. Ebert, et al.; Metabolism 58, 547 (2009)\n?Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome: J. Namkung, et al.; Metabolism 60, 564 (2011)\n?

Additional Info

Detects human ANGPTL6. Does not cross-react with human ANGPTL3, human ANGPTL4 or human ANGPTL7.

Alternative Names

Angiopoietin-like Protein 6, AGF, Angiopoietin-related Growth Factor