Supplier:
Alomone Labs Ltd.Cat no: A-520
Anisomycin
Anisomycin has been widely used as an extremely potent activator of kinase cascades in mammalian cells, especially the stress-activated protein kinase (SA10/PK2/p38\\MA10/PK\\), kinase subtypes and p46/54\\JNK\\.
Synergizes with growth factors and phorbol esters, anisomycin superinduce c-fos and c-jun by a number mechanisms, one of which is its ability to act as a potent signalling agonist, producing strong, prolonged activation of the same nuclear responses as epidermal growth factor or tetradecanoyl phorbol acetate. Anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor and by that blocked the insulin-induced tyrosine phosphorylation of IRS proteins. Protein Kinase Inhibitors and Activators; MA10/PK and MA10/PK Homolog Activator. Cell Signaling Activators and Inhibotors; Protein Synthesis and Transport Inhibitors.
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SPECIFICATIONS
Catalog Number
A-520
Size
10 x 1 mg
Purity
>98%
Concentration
0.1-10 micro M
Shipping Temp
Room Temperature
Molecular Weight
265.3
SUPPLIER INFO
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