Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC)

Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. \n\nSoubility (10mg/ml EtOAc):\nColorless, clear, complete\n\nAssay (HPLC): (same/more than)98%\n\nMelting Point: 139-145C\n\nWater (KF): (same/less than)1%\n\nEthyl Acetate (GC-MS): (same/less than)0.72%\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethyl acetate. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and moisture.

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SPECIFICATIONS

Catalog Number

A2296-90

Size

25mg

Form

Supplied as a white crystalline powder

References

1. Anisomycin, a new antiprotozoa antibiotic. Sobin B.A. & Tanner F.W. Jr., J. Am. Chem. Soc. 1954, 76, 4053 2. Selective inhibition of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino A.J. & Patterson S.D., J. Biol. Chem. 1997, 272, 7013. 3. Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38 (MAP kinase) activation and protein synthesis inhibition in mammalian cells. Barros L.F. et al., J. Physiol. 1997, 504, 517. 4. Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. Xing F. et al., J. Immunother. 2008, 31, 858.