Annexin 31, Recombinant, Human (ANXA9, ANX31)

The annexins are a family of calcium-dependent phospholipid-binding proteins. Annexin 31 cDNA encodes a 338-amino acid protein with less than 40% identity to other annexins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. The most striking feature of annexin 31 is a complete ablation of all four homologous type II calcium-binding sites in the conserved tetrad core. Although all 4 type II calcium-binding sites in annexin 31 contained amino acid substitutions that ablated their function, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. \n\nSource: E. coli\n\nDomain (aa): 1-338\n\nTag/Fusion Partner: T7 Tag at N terminus\n\nApplications:\nSuitable for use in ELISA, Western Blot and MS. Other applications not tested.\n\nQuality Control: SDS-PAGE \n\nStorage and Stability: \nFor long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. \n\nImportant note: This recombinant enzyme has NOT been tested with regard to biological activity.

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