Annexin 7, Recombinant, Human (ANX7, Synexin)

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin VII has molecular weight of approximately 51 kD with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.\n\nDescription: \nRecombinant Human Annexin-A7 produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-466) and having a total molecular mass of 53.6kD. Recombinant ANXA7 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques.\n\nApplications: \n

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SPECIFICATIONS

Catalog Number

A2296-67D

Size

2ug

Form

Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% sodium azide and 10mM DTT.

Purity

(same/more than) 90% as determined by the analysis by reducing and non-reducing SDS-PAGE coomassie blue staining.

References

1. Annexin 7-immunoreactive microglia in the hippocampus of control and adrenalectomized rats. Neurosci Lett 2005 May 20-27;380(1-2):42-7 2. Annexin 7 mobilizes calcium from endoplasmic reticulum stores in brain. Biochim Biophys Acta 2004 Dec 6;1742(1-3):151-60 3. Annexin 7: a non-SNARE proteolytic substrate for botulinum toxin type C in secreting chromaffin cells. Ann N Y Acad Sci 2002 Oct;971:287-90 4. Protein kinase C and guanosine triphosphate combine to potentiate calcium-dependent membrane fusion driven by annexin 7. J Biol Chem 2002 Jul 12;277(28):25217-25 5. Is annexin 7 a tumor suppressor gene in prostate cancer? Pharmacogenomics J 2001;1(2):92-4 6. Activation of annexin 7 by protein kinase C in vitro and in vivo. J Biol Chem 2001 Apr 20;276(16):12813-21