Annexin 9, Recombinant, Human (ANX9)

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. The most striking feature of annexin 31 is a complete ablation of all four homologous type II calcium-binding sites in the conserved tetrad core. Although all 4 type II calcium-binding sites in annexin 31 contained amino acid substitutions that ablated their function, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.\n\nDescription: \nRecombinant Human Annexin A9 produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-338) and having a total molecular mass of 38.9kD. Recombinant ANXA9 contains T7 tag at N-terminus and is purified by proprietary chromatographic techniques.\n\nApplications: \n

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SPECIFICATIONS

Catalog Number

A2296-68H

Size

2ug

Form

Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100 and 0.002% sodium azide.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Structural and functional characterisation of the mouse annexin A9 promoter. Biochim Biophys Acta 2004 Dec 6;1742(1-3):141-9 2. Atypical properties displayed by annexin A9, a novel member of the annexin family of Ca(2+) and lipid binding proteins. FEBS Lett 2003 Jul 10;546(2-3):359-64