Annexin IV (Annexin A4, 35-beta Calcimedin, Annexin-4, Carbohydrate-binding Protein p33/p41, Chromobindin-4, Endonexin I, Lipocortin IV, P32.5, PP4-X, Placental Anticoagulant Protein II, PAP-II, Protein II, ANXA4, ANX4)

Annexin IV, also known as placental anticoagulant protein II, or zymogen granule membrane-associated protein, 36kD (ZAP36), is one of the family of calcium-dependent phospholipid-binding proteins whose normal function is uncertain. Annexin IV has 45 to 59% identity with other members of the annexin family. Annexin IV gene spans 18-56kb. And it is located on mouse chromosome 6 in a region of conserved synteny with human chromosome 2. Rat annexin IV is ubiquitously expressed in epithelial tissues. Zap36 associated with zymogen granule membranes in dog and rat pancreas. Human annexin IV gene is mapped to chromosome 2p13. \n\nApplications:\nSuitable for use in Western Blot, Immunoprecipitation, and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot:1-2ug/ml \nImmunohistochemistry(paraffin):1-2ug/ml \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

A2295-15D5

Size

100ug

Applications

ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Rabbit

Form

Supplied as a liquid in PBS, pH 7.4, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Tait, J. F.; Smith, C.; Frankenberry, D. A.; Miao, C. H.; Adler, D. A.; Disteche, C. M. Chromosomal mapping of the human annexin IV (ANX4) gene. Genomics 12: 313-318, 1992. 2. Ponnampalam AP, Rogers PA.Cyclic changes and hormonal regulation of annexin IV mRNA and protein in human endometrium. Mol Hum Reprod. 2006 Nov;12(11):661-9. Epub 2006 Sep 5 3. Zschornig O, Opitz F, Muller M.Annexin A4 binding to anionic phospholipid vesicles modulated by pH and calcium.Eur Biophys J. 2007 Apr;36(4-5):415-24. Epub 2007 Mar 16.

Additional Info

Recognizes human Annexin IV. Species Cross-Reactivity: mouse, rat, rabbit.