ANO7 (Anoctamin-7, Dresden Transmembrane Protein of the Prostate, D-TMPP, IPCA-5, New Gene Expressed in Prostate, Prostate Cancer-associated Protein 5, Transmembrane Protein 16G, NGEP, PCANAP5, TMEM16G)

NGEP is a prostate-specific protein that belongs to the TMEM16 family and consists of TM16H1, TM16H2 and TM16H3 domains. NGEP gene located at human chromosome 2q37.3, is expressed as two splice variants and encodes two different size proteins. The larger (NGEP-L) is derived from 18 exons, encodes a protein that is predicted to contain seven-membrane-spanning regions and is localized to the plasma membrane. The smaller (NGEP-S) is derived from four exons, encodes an intracellular protein and detected in the cytoplasm of the cell. Because of its selective expression in prostate cancer and its presence on the cell surface, NGEP is a promising target for the antibody-based therapies of prostate cancer. The protein also plays an important role in cell-cell interactions.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

A2296-73A

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum.

Isotype

IgG

References

1. Bera, TK. et al. Proc. Natl. Acad. Sci. U.S.A. 101:3059-3064 (2004). 2. Kiessling, A. et al. Prostate. 64:387-400 (2005). 3. Katoh, M. et al. Int. J. Mol. Med. 14:759?764 (2004).

Additional Info

Recognizes human ANO7. Species sequence homology: mouse and rat.