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Ansatrienin A (Mycotrienin I, Antibiotic T 23I, T 23I)

Cat no: A2296-74


Supplier: United States Biological
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Ansatrienin A, isolated from a Streptomyces sp., is closely related to the Cytotrienins. It displays potent anticancer activity against cell lines and inhibits osteoclastic bone resorption. Ansatrienin A also significantly potentiates the action of several clinical anti-cancer agents. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO Related to: Ansatrienin B1.
Catalogue number: A2296-74
Size: 1mg
Purity: >95% by HPLC
Alternative names: Mycotrienin I, Antibiotic T 23I, T 23I
References: 1. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption. Feuerbach D. et al. J. Biol. Chem. 1995, 270, 25949. 2. Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluoro-uracil by mycotrienins and mycotrienols. Kuwano M. et al. Gann. 1983, 74, 759. 3. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II. Sugita M. et al. J. Antibiot. 1982, 35, 1467.

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