Home  >  Products  >  Anterior Pharynx Defective 1 Homolog A (APH1A, 6530402N02RIK, APH-1A, APH-1alpha, CGI-78, PSF, UNQ579/PRO1141)
Anterior Pharynx Defective 1 Homolog A (APH1A, 6530402N02RIK, APH-1A, APH-1alpha, CGI-78, PSF, UNQ579/PRO1141)

Anterior Pharynx Defective 1 Homolog A (APH1A, 6530402N02RIK, APH-1A, APH-1alpha, CGI-78, PSF, UNQ579/PRO1141)

Cat no: A2296-83

Supplier: United States Biological
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APH1 was initially identified as a component of the Notch pathway in C. elegans (1). Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma- secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid Beta peptide (ABeta) cleavage product that is associated with Alzheimer
Catalogue number: A2296-83
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Goutte C, et al (2002) Proc. Natl. Acad. Sci. USA. 99:775-9. 2. Periz G, et al (2004) J. Neurosci. Res. 77:309-22. 3. Selkoe DJ (1998) Trends Cell Biol. 8:447-53. 4. Ma G, et al (2005) Neuro. Dis. 25:192-8. 5. Serneels L, et al (2005) Proc.
Additional info: Recognizes Human Anterior Pharynx Defective 1 Homolog A (APH1A). Species Crossreactivity: Human, Mouse.

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