Anterior Pharynx Defective 1 Homolog A (APH1A, 6530402N02RIK, APH-1A, APH-1alpha, CGI-78, PSF, UNQ579/PRO1141)

Supplier:

United States Biological

Cat no: A2296-83A

Anterior Pharynx Defective 1 Homolog A (APH1A, 6530402N02RIK, APH-1A, APH-1alpha, CGI-78, PSF, UNQ579/PRO1141)

Anterior Pharynx-Defective 1 (APH1), in addition to presenilin, PEN2, and Nicastrin forms the g-secretase protein complex. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. The g-secretase complex can cleave the beta-amyloid (A4) precursor protein and yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Three mammalian homologues of APH1 have been identified: APH1a, APH1b, and APH1c, of which APH1a is more abundantly expressed than APH1b in human tissue samples. In addition, two isoforms of APH1a can be generated from alternative splicing of APH-1a, APH1a long form (APH1aL) and APH1a short form (APH1aS) that diverge at the C-terminus. APH1a is the major mammalian APH1 isoform required for Notch signaling during embryogenesis and the major APH1 isoform required for the assembly of the g-secretase complexes and APP processing. \n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.05-0.2ug/ml\nWestern Blot: 0.5-2.0ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nFor long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A2296-83A

Size

40ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 30% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

G Ma. et al. Journal of Neuroscience (2005), 25(1):192-198

Additional Info

Recognizes endogenous levels of human and mouse APH1a.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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