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Anti-3-Nitrotyrosine monoclonal antibody, clone 3B13

Cat no: DMAB8425


Supplier: Creative Diagnostics
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Mouse anti-3-Nitrotyrosine monoclonal antibody for WB. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxidesignaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A (SP-A) to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.55 kD 160 kD
Catalogue number: DMAB8425
Hosts: Mouse
Conjugates: Unconjugated
Clone: 3B13
Target: Tyrosine
Isotype: IgG1
Clonality: Monoclonal
Storage temp: Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles. And stable for one year from purchase when stored properly

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