Mouse anti-8-Hydroxyguanosine monoclonal antibody for ELISA, IHC. Suitable for use in ELISA and immunohistochemistry (PLP-fixed sections) to detect the markers of oxidative damage to DNA and RNA. May also be used on immunoaffinity columns to isolate oxidative DNA damage adducts from biological fluids. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.8-Hydroxyguanosineis anucleoside which is an oxidative derivative of guanosine. Measurement of thelevels of 8-hydroxyguanosine is used as a biomarker of oxidative stress. 8-Hydroxydeoxyguanosine (8OHdG) is a modified base thatoccurs in DNA due to attack by hydroxyl radicals that are formed asbyproducts and intermediates of aerobic metabolism and during oxidativestress. There is increasing evidence to support the involvement of freeradical reactions in the damage of biomolecules that eventually lead toseveral diseases in humans, such as atherosclerosis, cerebral and heartischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation,diabetes, aging, and neurodegenerative conditions, such as Alzheimer'sdisease
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