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Anti-Akt (Phospho S473) monoclonal antibody, clone SN362

Cat no: CABT-BL8522

Anti-Akt (Phospho S473) monoclonal antibody, clone SN362

Rabbit Anti-Human Akt (Phospho S473) monoclonal antibody for IHC,WB. The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

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SPECIFICATIONS

Catalog Number

CABT-BL8522

Hosts

Rabbit

Reactivities

Hum, Mouse

Clone

SN362

Target

AKT1

Gene Id

207

Isotype

IgG

Clonality

Monoclonal

Storage Temp

Stable for 1 Year at -20.0В°C from date of receipt

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