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Anti-alpha 1 Catenin (Internal) polyclonal antibody, clone O4D3

Cat no: CABT-B390

Anti-alpha 1 Catenin (Internal) polyclonal antibody, clone O4D3

Rabbit Anti-Human alpha 1 Catenin polyclonal antibody for ICC/IF, IHC-Fr, IHC-P, WB. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

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SPECIFICATIONS

Catalog Number

CABT-B390

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Clone

O4D3

Target

CTNNA1

Isotype

IgG

Clonality

polyclonal

Storage Temp

Keep as concentrated solution. Aliquot and store at -20В°C or below. Avoid multiple freeze-thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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