Anti-Aprataxin polyclonal antibody

Rabbit Anti-Human Aprataxin polyclonal antibody for WB, IP. Aprataxin (UniProt Q7Z2E3; also known as FHA-HIT, Forkhead-associated domain histidine triad-like protein) is encoded by the APTX (also known as AOA, AOA1, AXA1, EAOH, EOAHA) gene (Gene ID 54840) in human. Aprataxin contains an N-terminal forkhead-associated (FHA; a.a. 38-87) domain akin to that found in the DNA end damage repair factor polynucleotide kinase phosphatase (PNKP), followed by a histidine triad (HIT; a.a. 182-287) domain found in nucleoside hydrolases and transferases, and a C-terminal C2H2 type Zinc finger domain. Aprataxin exhibits both DNA- and RNA-binding activity and plays a role in reversing toxic 5-adenylated (5-AMP) DNA lesions generated by DNA ligases when encountering nicked DNA structures with abnormal DNA termini. Aprataxin functions as a DNA ligase proofreader to directly reverse damaged 5?-adenylated termini of DNA strand breaks that have been subjected to DNA damage-induced abortive processing by DNA ligases. Ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive neurological syndrome caused by an impairment in DNA repair as a result of APTX gene mutations. The related type 2 disorder AOA2 is caused by a Senataxin-deficiency due to SETX gene mutations.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

CABT-B1916

Hosts

Rabbit

Reactivities

Hum

Target

APTX

Gene Id

54840

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.