Anti-ATP6V0E1 polyclonal antibody

Rabbit Anti-ATP6V0E1 polyclonal antibody for WB, IHC. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3.

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SPECIFICATIONS

Catalog Number

CABT-B8778

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Conjugates

Unconj

Target

ATP6V0E1

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Store antibody at 4В°C, stable for 6 months. For long-term storage, store at -20В°C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.