anti-BCL2-Associated X Protein (BAX) antibody: Bax belongs to a family of proteins sharing homology with Bcl-2 oncoprotein in several highly conserved regions. The Bcl-2-related proteins are involved in the regulation of apoptosis, acting to promote or suppress cell death. Overexpression of Bax functions to promote cell death. It has been proposed that the relative expression of the different Bcl-2 family proteins controls the sensitivity of cells to apoptotic stimuli. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.
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