Rabbit anti-Human C4c polyclonal antibody for IHC. The Complement System is a plasma-based protein cascade, which functions as a highly regulated and effective immune barrier in the presence or absence of antibody. It is comprised of four main protein pathways that regulate and influence each other. The classical pathway (CP), so called because it was the first to be discovered, responds to immune complexes (aggregates of immunoglobulin) and to bound immunoglobulin (IgG and IgM specifically). The Alternative Pathway (AP) responds to a variety of chemical moieties including lipopolysaccharides, the primary constituent of bacterial cell walls. The newly described Mannose Binding Lectin (MBL) pathway is triggered by the binding of MBL (a protein that closely resembles C1q of the classical pathway) to a surface. While it has many potent biologic activities, the fourth pathway, the terminal pathway (TP), culminates in the formation of a protein ring called TCC or the Terminal Complement Complex.
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