Rabbit anti-Rat Ca2+/Calmodulin Kinase II (aa 7-20) polyclonal antibody for WB. Ca2+/calmodulin-dependent protein kinases II or CaM kinases II are serine/threonine-specific protein kinases that are regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman's syndrome, and heart arrhythmia. Calcium/calmodulin-dependent protein kinase II (CaMKII) is an enzyme that accounts for 1-2% of all of the proteins in the brain. This kinase can exist as 28 different isoforms. The isoforms of CaMKII derive from the alpha, beta, gamma, and delta genes.
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