Anti-Carboxy Methyl Lysine (C-terminal) polyclonal antibody

Goat anti-Carboxy Methyl Lysine (C-terminal) polyclonal antibody for WB, ELISA. Suitable for use in Western blot and ELISA (1:200вЂ“1:20,000). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.N epsilon carboxymethyl lysine (CML or Carboxymethyl Lysine) is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy.

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SPECIFICATIONS

Catalog Number

DPAB1525

Applications

ELISA

Hosts

Goat

Conjugates

Unconj

Target

CML

Clonality

Polyclonal

Storage Temp

Short term store at 2вЂ“8В°C. Long term store at -20В°C. Avoid multiple freeze/thaw cycles.  Slight precipitation may В°Ccur on storage which can be removed by centrifugation and should not affect performance characteristics.