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Anti-CD163 monoclonal antibody, clone FE3 [Biotin]

Anti-CD163 monoclonal antibody, clone FE3 [Biotin]

Cat no: DMABT-47168MR

Supplier: Creative Diagnostics
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Mouse anti-Rat CD163 monoclonal antibody for FC. CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Catalogue number: DMABT-47168MR
Reactivities: Rat
Hosts: Mouse
Conjugates: Biotin
Clone: FE3
Gene: 9332
Target: CD163
Isotype: IgG1
Clonality: Monoclonal
Storage temp: Store at +4 oC or at -20 oC if preferred. This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

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