anti-CD19 Molecule (CD19) (C-Term) antibody

anti-CD19 Molecule (CD19) (C-Term) antibody: The antibody reacts with the CD19 antigen which is also known as B4. CD19 is a Type I membrane glycoprotein with a molecular weight of 95 kDa. CD19 is involved in the development, activation and differentiation of B-cells. The molecule is expressed on the cell membrane of normal B-cells and pre-B-cells and downregulated during terminal maturation to plasma cells, which are negative for CD19. Positive immunostaining of CD19 is also observed on the cell membrane of follicular dendritic cells as well as in early stages of myelomonocytic cells. T-cells, NK-cells, monocytes and granulocytes are negative for CD19. CD19 is used as a pan-B cell marker. Compared to CD20, the classical pan-B marker in immunohistochemistry, CD19 is somewhat lower expressed in some B-cell neoplasias. Immunohistochemistry (IHC) is a complex technique in which immunological and histological detection methods are combined. In general, the manipulation and processing of tissues before immunostaining, especially different types of tissue fixation and embedding, as well as the nature of the tissues themselves may cause inconsistent results (Nadji and Morales, 1983). Endogenous pseudoperoxidase and peroxidase activity or endogenous biotin and alkaline phosphatase activity can cause non-specific staining results depending on the detection system used. Tissues that contain Hepatitis B surface antigen (HBsAg) can produce false positives when using HRP detection systems (Omata et al, 1980). Insufficient contrast staining and/or improper mounting of the sample may influence the interpretation of results.

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