Anti-CD3 monoclonal antibody, clone GO-29 [FITC]

Mouse anti-Rhesus Monkey CD3 monoclonal antibody for IHC, FC. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

DMABT-50502MM

Hosts

Mouse

Clone

GO-29

Target

CD3e

Gene Id

916

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

Prior to reconstitution store at +4 oC. Following reconstitution store at -20 oC.This product should be stored undiluted.Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.