anti-CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E) antibody (FITC): The antibody detects: Mouse CD3 (Mr 25 kDa) The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and nave T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL's. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.